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상순의 발생 -review-
Development of the Upper Lip -review-

대한구순구개열학회지 2007년 10권 1호 p.17 ~ 22

고승오, 임양희, 김기병, 신효근,

소속 상세정보

고승오 ( Ko Seung-O ) - 전북대학교 치의학전문대학원 구강안악면외과학교실
임양희 ( Im Yang-Hee ) - 전북대학교 치의학전문대학원 구강안악면외과학교실
김기병 ( Kim Ki-Byeung ) - 전북대학교 치의학전문대학원 구강안악면외과학교실
신효근 ( Shin Hyo-Keun ) - 전북대학교 치의학전문대학원 구강안악면외과학교실

KMID : 0952820070100010017

Abstract

The vertebrate upper lip forms from initially freely projecting maxillary, medial nasal, and lateral nasal prominences at the rostral and lateral boundaries of the primitive oral cavity. These facial prominences arise during early embryogenesis from ventrally migrating neural crest cells in combination with the head ectoderm and mesoderm and undergo directed growth and expansion around the nasal pits to actively fuse with each other. Initial fusion is between lateral and medial nasal processes and is followed by fusion between maxillary and medial nasal processes. Fusion between these prominences involves active epithelial filopodial and adhering interactions as well as programmed cell death. Slight defects in growth and patterning of the facial mesenchyme or epithelial fusion result in cleft lip with or without cleft palate, the most common and disfiguring craniofacial birth defect. This review will summarize the current understanding of the basic morphogenetic processes and molecular mechanisms underlying upper lip development.